Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.70 |
| ▸ | CYP1A1 | P04798 | 11/20 | 0.70 |
| ▸ | CYP1B1 | Q16678 | 11/20 | 0.70 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.60 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.60 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.60 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.60 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826746 | 1.00 | TLR9 (0.80) | TLR9CYP1A2CYP1A1CYP1B1NFE2L2 | |
| SCHEMBL13018896 | 0.90 | PTGS2 (0.78) | TLR9CYP1A2CYP1A1CYP1B1NFE2L2 | |
| SCHEMBL3054759 | 0.87 | TLR9 (0.76) | TLR9CYP1A2CYP1A1CYP1B1NFE2L2 | |
| SCHEMBL3054757 | 0.87 | TLR9 (0.76) | TLR9CYP1A2CYP1A1CYP1B1NFE2L2 | |
| SCHEMBL17991986 | 0.86 | TLR9 (0.65) | TLR9CYP1A2CYP1A1CYP1B1NFE2L2 | |
| SCHEMBL6721800 | 0.86 | TLR9 (0.71) | TLR9CYP1A2CYP1A1CYP1B1NFE2L2 | |
| SCHEMBL5495428 | 0.83 | CYP1A2 (1.00) | CYP1A2CYP1A1CYP1B1NFE2L2CYP19A1 | |
| SCHEMBL1005735 | 0.83 | PTGS2 (0.78) | TLR9NFE2L2PTGS2PTGS1CYP19A1 | |
| SCHEMBL5495431 | 0.83 | CYP1A2 (1.00) | CYP1A2CYP1A1CYP1B1NFE2L2CYP19A1 | |
| SCHEMBL1005734 | 0.83 | PTGS2 (0.78) | TLR9NFE2L2PTGS2PTGS1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221346-B1 | (N-SUBSTITUTED-2-HYDROXY) BENZAMIDES AND N-SUBSTITUTED-2-HYDROXY-ALPHA-OXO-BENZENEACETAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF HAVING ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE | WARNER-LAMBERT COMPANY (US) | 1991-01-30 | — | — | EP | disclosed |
| US-4939133-A | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| US-4921871-A | LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1990-05-01 | — | — | US | disclosed |
| US-4874758-A | LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-10-17 | — | — | US | disclosed |
| US-4868205-A | ANTIALLERGENS, ANTIINFLAMMATORY, CARDIOVASCULAR DISORDERS | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4868195-A | ENZYME INHIBITORS, ANTIALLERGEN, ASTHMA, CARDIOVASCULAR, ANTIINFLAMMATORY | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4868200-A | LEUKOTRIENES, LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4868199-A | ENZYME INHIBITORS, ANTIALLERGEN, ASTHMA, CARDIOVASCULAR, ANTIINFLAMMATORY | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4761424-A | Enolamides, pharmaceutical compositions and methods for treating inflammation | WARNER-LAMBERT COMPANY (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0221346-A1 | (N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |
| EP-0221345-A1 | Novel enolamides, process for their manufacture and pharmaceutical compositions thereof with an activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |