Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828412 | 0.93 | CHRM2 (0.46) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL9827919 | 0.92 | LMNA (0.47) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL9827932 | 0.91 | CYP2D6 (0.50) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL9827349 | 0.89 | HRH1 (0.53) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL9827728 | 0.86 | FFAR1 (0.35) | KCNH2CYP2D6CYP2C19SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9827508 | 0.86 | GRIN2D (0.36) | KCNH2CYP2D6TSHRLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9827657 | 0.85 | FFAR1 (0.34) | KCNH2CYP2D6CYP2C19SIGMAR1 | |
| SCHEMBL9828576 | 0.81 | HRH4 (0.39) | ADRA2ASLC6A3KCNH2ADRA1AHRH1 | |
| SCHEMBL10372681 | 0.81 | SSTR4 (0.42) | SSTR4SSTR2GBA1 | |
| Hydrochloric Acid SCHEMBL9827176 | 0.81 | GRIN2D (0.40) | ADRA2ASLC6A3KCNH2ADRA1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0302896-B1 | N-(W-SUBSTITUTED ALKYL)-N'-[(IMIDAZOLE-4-YL)ALKYL]GUANIDINE | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-08-14 | — | — | EP | claimed |
| EP-0302896-B1 | N-(W-SUBSTITUTED ALKYL)-N'-[(IMIDAZOLE-4-YL)ALKYL]GUANIDINE | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-08-14 | — | — | EP | disclosed |