Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29033709 | 0.80 | P2RX7 (0.42) | P2RX7PIK3CDDPP4BRD4BRD2 | |
| SCHEMBL9829476 | 0.78 | MAPK1 (0.31) | — | |
| SCHEMBL24711921 | 0.78 | P2RX7 (0.43) | P2RX7PIK3CDDPP4BRD4BRD2 | |
| SCHEMBL9829835 | 0.77 | — | — | |
| SCHEMBL9828335 | 0.76 | NOTUM (0.35) | NOTUM | |
| SCHEMBL5508211 | 0.75 | P2RX7 (0.47) | P2RX7PIK3CDDPP4BRD4BRD2 | |
| SCHEMBL10274994 | 0.75 | CYP1A2 (0.48) | P2RX7PIK3CDDPP4BRD4BRD2 | |
| SCHEMBL23583854 | 0.74 | P2RX7 (0.44) | P2RX7PIK3CDDPP4 | |
| Hydrochloric Acid SCHEMBL9836222 | 0.74 | P2RX7 (0.41) | P2RX7PIK3CDDPP4BRD4BRD2 | |
| Hydrochloric Acid SCHEMBL9835431 | 0.74 | PIK3CD (0.39) | P2RX7PIK3CDDPP4BRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | claimed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | claimed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | claimed |
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |