Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.48 |
| ▸ | HNF4A | P41235 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924845 | 0.84 | ALOX5 (0.57) | BACE1ALOX5CYP1A2ALDH1A1LMNA | |
| SCHEMBL50409 | 0.83 | BACE1 (0.62) | BACE1ALOX5CYP1A2ALDH1A1LMNA | |
| SCHEMBL9716759 | 0.82 | BACE1 (0.61) | BACE1ALOX5CYP1A2ALDH1A1LMNA | |
| Ethane SCHEMBL27845038 | 0.80 | APP (0.56) | ALOX5CYP1A2ALDH1A1KDM4EMAPT | |
| SCHEMBL1023129 | 0.80 | HSD17B1 (0.66) | BACE1ALOX5CYP1A2ALDH1A1LMNA | |
| SCHEMBL28053825 | 0.79 | ALOX5 (0.83) | BACE1ALOX5CYP1A2ALDH1A1LMNA | |
| SCHEMBL29738649 | 0.78 | MEN1 (0.62) | BACE1ALOX5CYP1A2ALDH1A1LMNA | |
| SCHEMBL8188895 | 0.78 | DPP4 (0.48) | BACE1ALOX5CYP1A2ALDH1A1LMNA | |
| SCHEMBL8992573 | 0.78 | MEN1 (0.62) | BACE1ALOX5CYP1A2ALDH1A1LMNA | |
| SCHEMBL3804563 | 0.78 | TAAR1 (0.50) | BACE1ALOX5CYP1A2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013021309-A1 | INTERMEDIATE AND PROCESS FOR THE PREPARATION OF A SULFONAMIDE DERIVATIVE | PFIZER LIMITED (GB) | 2013-02-14 | — | — | WO | disclosed |
| EP-0221346-B1 | (N-SUBSTITUTED-2-HYDROXY) BENZAMIDES AND N-SUBSTITUTED-2-HYDROXY-ALPHA-OXO-BENZENEACETAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF HAVING ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE | WARNER-LAMBERT COMPANY (US) | 1991-01-30 | — | — | EP | disclosed |
| EP-0221346-A1 | (N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |