Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 12/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829067 | 0.84 | CA2 (0.70) | CA2SLC6A4SLC6A3SLC6A2POLB | |
| SCHEMBL9830133 | 0.81 | CA2 (0.49) | CA2GAA | |
| SCHEMBL9827904 | 0.78 | CA2 (1.00) | CA2SLC6A4SLC6A3SLC6A2POLB | |
| Hydrochloric Acid SCHEMBL29426319 | 0.77 | CA2 (0.97) | CA2SLC6A4SLC6A3SLC6A2POLB | |
| SCHEMBL9829756 | 0.77 | CA2 (0.48) | CA2SLC6A4SLC6A2POLBKDM4E | |
| SCHEMBL9828921 | 0.75 | CA2 (0.52) | CA2MEN1ALDH1A1GAAKMT2A | |
| SCHEMBL10387650 | 0.71 | CA2 (0.40) | CA2 | |
| SCHEMBL10388257 | 0.71 | CA2 (0.38) | CA2ALDH1A1 | |
| SCHEMBL9831048 | 0.68 | CA2 (0.43) | CA2 | |
| Hydrochloric Acid SCHEMBL7572821 | 0.68 | CA2 (0.77) | CA2POLBGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |