Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 16/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828921 | 0.86 | CA2 (0.52) | CA2CA12CA9CA1RAPGEF4 | |
| SCHEMBL9831048 | 0.83 | CA2 (0.43) | CA2CA12CA9CA1RAPGEF4 | |
| SCHEMBL9828431 | 0.81 | CA2 (0.64) | CA2GAA | |
| SCHEMBL9828452 | 0.80 | CA2 (0.54) | CA2CA12CA9CA1RAPGEF4 | |
| SCHEMBL10388257 | 0.78 | CA2 (0.38) | CA2 | |
| SCHEMBL10387650 | 0.76 | CA2 (0.40) | CA2 | |
| SCHEMBL9830147 | 0.75 | CA2 (0.40) | CA2CA12CA9CA1 | |
| SCHEMBL9829741 | 0.70 | CNR1 (0.53) | CA2GAAPKM | |
| SCHEMBL10388515 | 0.70 | CA2 (0.39) | CA2 | |
| SCHEMBL10649624 | 0.70 | CA2 (0.43) | CA2CA12CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |