Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.73 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828725 | 0.85 | CA2 (0.76) | CA2 | |
| SCHEMBL9829292 | 0.85 | CA2 (1.00) | CA2 | |
| Hydrochloric Acid SCHEMBL9830371 | 0.84 | CA2 (1.00) | CA2 | |
| SCHEMBL9829659 | 0.83 | CA2 (0.60) | CA2 | |
| SCHEMBL9829489 | 0.82 | CA2 (0.63) | CA2 | |
| SCHEMBL9827924 | 0.75 | CA2 (0.58) | CA2 | |
| SCHEMBL9829011 | 0.75 | LOX (0.52) | CA2 | |
| SCHEMBL10589348 | 0.74 | CA2 (0.59) | CA2 | |
| SCHEMBL9830819 | 0.73 | CA2 (0.67) | CA2 | |
| SCHEMBL22623436 | 0.72 | CA2 (0.53) | CA2OPRM1OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |