Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.77 |
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827904 | 0.87 | CA2 (1.00) | CA2POLBMAPTKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL29426319 | 0.86 | CA2 (0.97) | CA2POLBMAPTKDM4EMEN1 | |
| SCHEMBL9829437 | 0.81 | CA2 (0.67) | CA2POLB | |
| Hydrochloric Acid SCHEMBL7572821 | 0.80 | CA2 (0.77) | CA2POLBMAPTGAA | |
| SCHEMBL9829489 | 0.76 | CA2 (0.63) | CA2 | |
| SCHEMBL9832127 | 0.74 | CA2 (0.61) | CA2POLBMAPTALDH1A1GAA | |
| SCHEMBL29599097 | 0.72 | POLB (0.62) | CA2POLBMAPTALDH1A1GAA | |
| SCHEMBL4901587 | 0.72 | POLB (0.62) | CA2POLBMAPTALDH1A1GAA | |
| SCHEMBL5157299 | 0.72 | POLB (0.62) | CA2POLBMAPTALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL7572817 | 0.71 | CA2 (0.60) | CA2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | claimed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | claimed |
| JP-1056672-A | — | — | None | — | — | JP | disclosed |