Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.67 |
| ▸ | CA1 | P00915 | 8/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829489 | 0.87 | CA2 (0.63) | CA2CA1 | |
| SCHEMBL9828539 | 0.81 | CA2 (0.77) | CA2POLB | |
| SCHEMBL9827904 | 0.81 | CA2 (1.00) | CA2POLBLOX | |
| SCHEMBL9832127 | 0.81 | CA2 (0.61) | CA2CA1POLBCA12CA9 | |
| Hydrochloric Acid SCHEMBL29426319 | 0.80 | CA2 (0.97) | CA2POLBLOX | |
| SCHEMBL137017 | 0.77 | CA2 (0.45) | CA2CA1POLBCA12CA9 | |
| Hydrochloric Acid SCHEMBL7572821 | 0.77 | CA2 (0.77) | CA2POLBLOX | |
| SCHEMBL9829011 | 0.73 | LOX (0.52) | CA2CA1CA12CA9LOX | |
| SCHEMBL12809039 | 0.72 | POLB (0.56) | CA2CA1POLBCA12CA9 | |
| SCHEMBL4901587 | 0.71 | POLB (0.62) | CA2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |