Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193591 | 0.91 | DPP4 (0.53) | DPP4DRD3KMT2AMEN1NPC1 | |
| SCHEMBL10420409 | 0.88 | TSHR (0.53) | DPP4KMT2AMEN1NPC1TSHR | |
| SCHEMBL8471030 | 0.86 | GPR84 (0.56) | DPP4DRD3KMT2AMEN1NPC1 | |
| SCHEMBL27868596 | 0.85 | GPR84 (0.59) | DPP4DRD3KMT2AMEN1NPC1 | |
| SCHEMBL8473581 | 0.85 | GPR84 (0.59) | DPP4DRD3KMT2AMEN1NPC1 | |
| SCHEMBL10420359 | 0.81 | DPP4 (0.55) | DPP4KMT2AMEN1NPC1TSHR | |
| SCHEMBL7857050 | 0.77 | L3MBTL1 (0.52) | KMT2ANPC1HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL7248390 | 0.77 | KMT2A (0.43) | DRD3KMT2AMEN1NPC1TSHR | |
| SCHEMBL207882 | 0.75 | KMT2A (0.44) | DRD3KMT2AMEN1NPC1TSHR | |
| Benzoic Acid SCHEMBL569810 | 0.75 | TSHR (0.48) | TSHRCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-03-13 | — | — | EP | disclosed |
| EP-0395697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4 | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| WO-1989004303-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |