Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 13/20 | 0.70 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.56 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.53 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829001 | 1.00 | GPR139 (0.70) | GPR139SLC6A9SLC6A5MEN1KMT2A | |
| SCHEMBL4055985 | 0.87 | GPR139 (0.74) | GPR139SLC6A9SLC6A5MEN1KMT2A | |
| SCHEMBL22811219 | 0.86 | ALDH1A1 (0.56) | GPR139SLC6A9SLC6A5MEN1KMT2A | |
| SCHEMBL9831837 | 0.84 | GPR139 (0.59) | GPR139SLC6A9SLC6A5MEN1KMT2A | |
| SCHEMBL9831842 | 0.84 | GPR139 (0.59) | GPR139SLC6A9SLC6A5MEN1KMT2A | |
| SCHEMBL14660470 | 0.84 | KMT2A (0.59) | GPR139MEN1KMT2A | |
| SCHEMBL9830497 | 0.84 | GPR139 (0.67) | GPR139SLC6A9SLC6A5MEN1KMT2A | |
| SCHEMBL9830492 | 0.84 | GPR139 (0.67) | GPR139SLC6A9SLC6A5MEN1KMT2A | |
| SCHEMBL6670978 | 0.82 | GPR139 (0.63) | GPR139SLC6A9SLC6A5MEN1KMT2A | |
| SCHEMBL6670986 | 0.82 | GPR139 (0.63) | GPR139SLC6A9SLC6A5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |