Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.51 |
| ▸ | DHFR | P00374 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TLR4 | O00206 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TYMS | P04818 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19899438 | 0.87 | FOLH1 (0.50) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL19899429 | 0.87 | FOLH1 (0.50) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL9556349 | 0.84 | L3MBTL1 (0.54) | DHFRLMNAHSD17B10KDM4EALDH1A1 | |
| SCHEMBL29009588 | 0.82 | CA2 (0.61) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL29009589 | 0.82 | CA2 (0.61) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL27564186 | 0.79 | CA2 (0.75) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL8379946 | 0.78 | CA2 (0.66) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL1640055 | 0.78 | CA2 (0.66) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL11441280 | 0.78 | CA2 (0.56) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL9829320 | 0.77 | CA2 (0.52) | CA2CA1CA12CA9FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239362-B1 | ANTI-TUMOR AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-12-04 | — | — | EP | disclosed |
| EP-0239362-A2 | Anti-tumor agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-09-30 | — | — | EP | disclosed |