Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.64 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.64 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.64 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2273801 | 0.95 | ADRB1 (0.58) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL11068888 | 0.89 | ADRB1 (0.70) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL10472127 | 0.84 | CHRM2 (0.48) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL2940513 | 0.84 | CHRM2 (0.48) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL10239969 | 0.83 | CHRM2 (0.47) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL5591514 | 0.83 | ALDH1A1 (0.48) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL20556701 | 0.81 | TRIM24 (0.55) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL8204166 | 0.80 | ADRB1 (0.59) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL20370996 | 0.80 | CHRM2 (0.44) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL12372520 | 0.80 | ADRB1 (0.48) | ADRB1CHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |