Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.47 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829421 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL6249252 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL3663781 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL9828880 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL12067906 | 0.86 | ATM (0.47) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL9993761 | 0.86 | ATM (0.47) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL5224258 | 0.85 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL7357011 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL1461981 | 0.82 | ATM (0.60) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL11491274 | 0.82 | ATM (0.60) | SMN1; SMN2NPC1RAB9ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |