Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610217 | 0.89 | LMNA (0.50) | SMN1; SMN2RAB9ANPC1LMNACTSK | |
| SCHEMBL6249252 | 0.86 | SMN1; SMN2 (0.53) | SMN1; SMN2RAB9ANPC1LMNAPOLB | |
| SCHEMBL9828880 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9ANPC1LMNAPOLB | |
| SCHEMBL9829421 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2RAB9ANPC1LMNAPOLB | |
| SCHEMBL9829428 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2RAB9ANPC1LMNAPOLB | |
| SCHEMBL3663781 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9ANPC1LMNAPOLB | |
| SCHEMBL1461981 | 0.81 | ATM (0.60) | SMN1; SMN2RAB9ANPC1LMNAPOLB | |
| SCHEMBL11491274 | 0.81 | ATM (0.60) | SMN1; SMN2RAB9ANPC1LMNAPOLB | |
| SCHEMBL13387483 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9ANPC1LMNAPOLB | |
| SCHEMBL13506655 | 0.80 | NPSR1 (0.58) | SMN1; SMN2RAB9ANPC1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781649-A2 | SUBSTITUTED HYDANTOINS | F. Hoffmann-Roche AG (CH) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018188-A2 | SUBSTITUTED HYDANTOINS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-23 | — | — | WO | disclosed |