Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | CA2 | P00918 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.56 |
| ▸ | MME | P08473 | 5/20 | 0.52 |
| ▸ | ACE | P12821 | 4/20 | 0.52 |
| ▸ | CPA1 | P15085 | 2/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829407 | 1.00 | NPC1 (0.66) | NPC1RAB9ACA2CA1PTPN1 | |
| SCHEMBL9829719 | 0.91 | ACE (0.60) | CA2CA1PTPN1MMEACE | |
| SCHEMBL9829713 | 0.91 | ACE (0.60) | CA2CA1PTPN1MMEACE | |
| SCHEMBL10954969 | 0.90 | MME (0.61) | NPC1RAB9ACA2CA1PTPN1 | |
| SCHEMBL9829550 | 0.89 | MME (0.58) | CA2CA1PTPN1MMEACE | |
| SCHEMBL10662340 | 0.89 | PTPN1 (0.57) | CA2CA1PTPN1MMEACE | |
| SCHEMBL9829553 | 0.89 | MME (0.58) | CA2CA1PTPN1MMEACE | |
| SCHEMBL10662333 | 0.89 | PTPN1 (0.57) | CA2CA1PTPN1MMEACE | |
| SCHEMBL7442309 | 0.88 | CA2 (0.71) | NPC1RAB9ACA2CA1PTPN1 | |
| SCHEMBL7442291 | 0.88 | CA2 (0.71) | NPC1RAB9ACA2CA1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |