Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.62 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.60 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.60 |
| ▸ | CD74 | P04233 | 1/20 | 0.55 |
| ▸ | MIF | P14174 | 1/20 | 0.55 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | P4HB | P07237 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828698 | 0.92 | LOXL2 (0.54) | LOXL2CYP4F2CYP4A11CD74MIF | |
| SCHEMBL2069334 | 0.89 | LOXL2 (0.68) | LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4 | |
| SCHEMBL481432 | 0.88 | CYP4F2 (0.65) | LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4 | |
| Hydroquinone SCHEMBL28832812 | 0.87 | LOXL2 (0.66) | LOXL2CYP4F2CYP4A11CD74MIF | |
| SCHEMBL2515139 | 0.86 | LOXL2 (0.60) | LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4 | |
| SCHEMBL480988 | 0.86 | LOXL2 (0.60) | LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4 | |
| SCHEMBL8716270 | 0.83 | LOXL2 (0.60) | LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4 | |
| SCHEMBL12797648 | 0.83 | LOXL2 (0.64) | LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4 | |
| SCHEMBL481481 | 0.83 | CYP4F2 (0.67) | LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4 | |
| SCHEMBL10420734 | 0.82 | LOXL2 (0.59) | LOXL2CYP4F2CYP4A11CD74MIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051427-A | Antiinflammatory agents and antiallergens | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0395697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-03-13 | — | — | EP | disclosed |
| EP-0395697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4 | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989004303-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |