Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TLR4 | O00206 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583721 | 0.87 | ALDH1A1 (0.40) | MAPTLMNATLR4CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL10945868 | 0.86 | ALDH1A1 (0.40) | MAPTLMNATLR4CHRM2CHRM4 | |
| SCHEMBL9831234 | 0.81 | CHRM2 (0.48) | MAPTTLR4CHRM2CHRM4CHRM5 | |
| SCHEMBL29896656 | 0.80 | MAPT (0.42) | MAPTTLR4CHRM2CHRM4CHRM5 | |
| SCHEMBL9829537 | 0.79 | ALDH1A1 (0.48) | MAPTLMNATLR4CHRM2CHRM4 | |
| SCHEMBL9833333 | 0.78 | ALDH1A1 (0.49) | MAPTTLR4ALDH1A1MEN1KMT2A | |
| SCHEMBL9831077 | 0.76 | ALDH1A1 (0.47) | MAPTTLR4ALDH1A1MEN1KMT2A | |
| SCHEMBL9831742 | 0.76 | ALDH1A1 (0.52) | MAPTTLR4CHRM2CHRM4CHRM5 | |
| SCHEMBL9830385 | 0.73 | MAPT (0.49) | MAPTLMNATLR4CHRM2CHRM4 | |
| SCHEMBL15325151 | 0.73 | TLR4 (0.42) | MAPTLMNATLR4ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |