Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TLR4 | O00206 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831077 | 0.99 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL9832302 | 0.93 | MAPT (0.46) | ALDH1A1MEN1KMT2AMAPTTLR4 | |
| SCHEMBL19360216 | 0.81 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL864567 | 0.81 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL2048119 | 0.79 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL11568317 | 0.78 | MAPT (0.43) | ALDH1A1MEN1KMT2AMAPTTLR4 | |
| SCHEMBL9829971 | 0.78 | MAPT (0.41) | ALDH1A1MEN1KMT2AMAPTTLR4 | |
| SCHEMBL858179 | 0.75 | BRD4 (0.38) | — | |
| SCHEMBL9830385 | 0.75 | MAPT (0.49) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL9734800 | 0.74 | MAPT (0.56) | ALDH1A1MEN1KMT2ATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |