Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378609 | 0.79 | MAPT (0.57) | ALDH1A1MAPTSMN1; SMN2KDM4ETSHR | |
| SCHEMBL5360390 | 0.79 | CHRM5 (0.37) | — | |
| SCHEMBL9833337 | 0.78 | ALDH1A1 (0.47) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL26114095 | 0.77 | TP53 (0.41) | ALDH1A1MAPTSMN1; SMN2KDM4EHTT | |
| SCHEMBL1134499 | 0.74 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL1134501 | 0.74 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL13618163 | 0.74 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL29896656 | 0.74 | MAPT (0.42) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL9831080 | 0.73 | ALDH1A1 (0.42) | ALDH1A1MAPTSMN1; SMN2TSHRPOLB | |
| SCHEMBL5483 | 0.72 | ALDH1A1 (0.51) | ALDH1A1MAPTSMN1; SMN2KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |