Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830885 | 0.89 | ALDH1A1 (0.43) | TSHRMEN1KMT2AALDH1A1HTT | |
| SCHEMBL9832952 | 0.82 | ALDH1A1 (0.45) | TSHRMEN1KMT2AALDH1A1HTT | |
| SCHEMBL9831161 | 0.79 | ADRB1 (0.40) | MEN1KMT2AALDH1A1HTTHSD17B10 | |
| SCHEMBL10408235 | 0.78 | ALDH1A1 (0.35) | TSHRALDH1A1HTTHSD17B10MAPT | |
| SCHEMBL9830547 | 0.77 | ADRB1 (0.45) | TSHRMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL9831038 | 0.77 | ADRB1 (0.45) | ALDH1A1MAPTLMNAL3MBTL1FFAR4 | |
| SCHEMBL10407194 | 0.76 | MAPT (0.39) | MEN1KMT2AALDH1A1HTTMAPT | |
| SCHEMBL9831957 | 0.74 | COMT (0.46) | MEN1KMT2AALDH1A1HTTMAPT | |
| SCHEMBL9830884 | 0.72 | AKR1C3 (0.42) | HTTLMNAP2RX3P2RX2 | |
| SCHEMBL10408464 | 0.72 | HSD17B10 (0.56) | TSHRMEN1KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |