Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.61 |
| ▸ | CDC25B | P30305 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831109 | 0.82 | CYP1A1 (0.67) | CDC25ACDC25BMAPTALDH1A1KDM4E | |
| SCHEMBL9830244 | 0.80 | ALDH1A1 (0.63) | MAPTALDH1A1KDM4ERAB9AATM | |
| SCHEMBL13394699 | 0.80 | MAPT (0.73) | CDC25ACDC25BMAPTALDH1A1KDM4E | |
| SCHEMBL2096148 | 0.80 | MAPT (0.61) | CDC25ACDC25BMAPTALDH1A1KDM4E | |
| SCHEMBL1180215 | 0.80 | MAPT (0.84) | CDC25ACDC25BMAPTALDH1A1KDM4E | |
| SCHEMBL9831572 | 0.79 | SMN1; SMN2 (0.56) | MAPTALDH1A1KDM4ERAB9APOLB | |
| SCHEMBL20390901 | 0.79 | CYP19A1 (0.47) | CDC25ACDC25BMAPTALDH1A1KDM4E | |
| SCHEMBL2277599 | 0.79 | CDC25A (0.45) | CDC25ACDC25BMAPTALDH1A1KDM4E | |
| SCHEMBL28570238 | 0.79 | KDM4E (0.62) | CDC25ACDC25BMAPTALDH1A1KDM4E | |
| SCHEMBL2096147 | 0.79 | MAPT (0.59) | CDC25ACDC25BMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321115-B1 | CARBOXAMIDE DERIVATIVES HAVING TETRAZOLE AND THIAZOLE RINGS AND THEIR USE | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4946855-A | ANTIALLERGIC | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1990-08-07 | — | — | US | disclosed |
| EP-0321115-A1 | Carboxamide derivatives having tetrazole and thiazole rings and their use | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1989-06-21 | — | — | EP | disclosed |
| EP-0001727-B1 | NEW DERIVATIVES OF 4-PHENYL-2-(2',2',2-TRICHLORETHOXYCARBOXAMIDO)-THIAZOLE USEFUL AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THE PREPARATION OF THESE COMPOUNDS | PIERRE FABRE S.A. (FR) | 1981-11-11 | — | — | EP | disclosed |
| EP-0001727-A2 | New derivatives of 4-phenyl-2-(2',2',2-trichlorethoxycarboxamido)-thiazole useful as medicaments, pharmaceutical compositions containing them and process for the preparation of these compounds | PIERRE FABRE S.A. (FR) | 1979-05-02 | — | — | EP | disclosed |