Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9249991 | 0.88 | CACNA1B (0.45) | HTTCACNA1BADORA3MEN1KMT2A | |
| SCHEMBL7326485 | 0.88 | CACNA1B (0.45) | HTTCACNA1BADORA3MEN1KMT2A | |
| SCHEMBL7365756 | 0.82 | CACNA1B (0.40) | HTTCACNA1BADORA3MEN1KMT2A | |
| SCHEMBL7366816 | 0.80 | CACNA1B (0.39) | HTTCACNA1BADORA3MEN1KMT2A | |
| SCHEMBL7400371 | 0.80 | CYP2C9 (0.43) | HTTCACNA1BADORA3MEN1KMT2A | |
| SCHEMBL11023235 | 0.79 | ALDH1A1 (0.42) | HTTCACNA1BADORA3MEN1KMT2A | |
| SCHEMBL7283842 | 0.78 | MEN1 (0.38) | HTTCACNA1BADORA3MEN1KMT2A | |
| SCHEMBL11020903 | 0.75 | TP53 (0.35) | HTTCACNA1BALDH1A1MAPTTDP1 | |
| SCHEMBL10827655 | 0.75 | F2RL3 (0.36) | HTTADORA3MEN1KMT2ACACNA1C | |
| SCHEMBL3392135 | 0.75 | POLB (0.45) | ALDH1A1IRAK4MAPTTDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161877-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. (JP) | 1991-05-29 | — | — | EP | claimed |