Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 13/20 | 0.65 |
| ▸ | PPARG | P37231 | 8/20 | 0.65 |
| ▸ | PPARA | Q07869 | 12/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830223 | 0.88 | PPARD (0.50) | PPARDPPARGPPARAFFAR1 | |
| Romazarit SCHEMBL43265 | 0.86 | ALDH1A1 (0.50) | PPARDPPARGPPARAIKBKB | |
| Romazarit SCHEMBL3226211 | 0.85 | ALDH1A1 (0.49) | PPARDPPARGPPARAIKBKB | |
| SCHEMBL9831054 | 0.84 | PPARA (0.55) | PPARDPPARGPPARAPTPN1 | |
| SCHEMBL9831350 | 0.84 | PPARD (0.46) | PPARDPPARGPPARAFFAR1 | |
| SCHEMBL9831905 | 0.81 | NOTUM (0.44) | PPARDPPARGPPARAFFAR1 | |
| SCHEMBL3804094 | 0.80 | PPARD (0.66) | PPARDPPARGPPARAPTPN1IKBKB | |
| SCHEMBL6236889 | 0.79 | PPARD (1.00) | PPARDPPARGPPARAPTPN1FFAR1 | |
| SCHEMBL28781448 | 0.78 | PPARD (0.60) | PPARDPPARGPPARAPTPN1IKBKB | |
| SCHEMBL6224426 | 0.78 | PPARD (0.60) | PPARDPPARGPPARAPTPN1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220573-B1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | claimed |
| US-4774253-A | ETHER,-ACIDS, ESTERS OR AMIDES | HOFFMANN-LA ROCHE INC. (US) | 1988-09-27 | — | — | US | claimed |
| EP-0220573-A1 | Heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1987-05-06 | — | — | EP | claimed |
| EP-0220573-B1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4774253-A | ETHER,-ACIDS, ESTERS OR AMIDES | HOFFMANN-LA ROCHE INC. (US) | 1988-09-27 | — | — | US | disclosed |
| EP-0220573-A1 | Heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1987-05-06 | — | — | EP | disclosed |