Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 10/20 | 0.46 |
| ▸ | PPARG | P37231 | 8/20 | 0.46 |
| ▸ | PPARA | Q07869 | 7/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Romazarit SCHEMBL43265 | 0.86 | ALDH1A1 (0.50) | PPARDPPARGPPARAKDM4EALDH1A1 | |
| SCHEMBL9830223 | 0.86 | PPARD (0.50) | PPARDPPARGPPARAFFAR1VDR | |
| Romazarit SCHEMBL3226211 | 0.85 | ALDH1A1 (0.49) | PPARDPPARGPPARAKDM4EALDH1A1 | |
| SCHEMBL9830285 | 0.84 | PPARD (0.65) | PPARDPPARGPPARAFFAR1 | |
| SCHEMBL9831905 | 0.81 | NOTUM (0.44) | PPARDPPARGPPARAFFAR1VDR | |
| SCHEMBL9829580 | 0.77 | VDR (0.48) | PPARDPPARGPPARAFFAR1VDR | |
| SCHEMBL9830290 | 0.76 | KDM4E (0.41) | PPARDPPARGPPARAMAPTKDM4E | |
| SCHEMBL9831640 | 0.75 | ALDH1A1 (0.49) | PPARDPPARGPPARAFFAR1MAPT | |
| SCHEMBL9831297 | 0.74 | SLC16A3 (0.47) | PPARDPPARGPPARAMAPTALDH1A1 | |
| SCHEMBL9830056 | 0.74 | PPARA (0.50) | PPARDPPARGPPARAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220573-B1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | claimed |
| US-4774253-A | ETHER,-ACIDS, ESTERS OR AMIDES | HOFFMANN-LA ROCHE INC. (US) | 1988-09-27 | — | — | US | claimed |
| EP-0220573-A1 | Heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1987-05-06 | — | — | EP | claimed |
| EP-0220573-B1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4774253-A | ETHER,-ACIDS, ESTERS OR AMIDES | HOFFMANN-LA ROCHE INC. (US) | 1988-09-27 | — | — | US | disclosed |
| EP-0220573-A1 | Heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1987-05-06 | — | — | EP | disclosed |