Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.63 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | EHMT2 | Q96KQ7 | 5/20 | 0.48 |
| ▸ | EHMT1 | Q9H9B1 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1291766 | 0.77 | PGK1 (1.00) | PGK1POLB | |
| SCHEMBL3980055 | 0.76 | PGK1 (0.62) | PGK1TLR9POLB | |
| SCHEMBL7262661 | 0.75 | PGK1 (0.61) | PGK1TLR9POLB | |
| SCHEMBL8758459 | 0.75 | NPY1R (0.56) | POLBEHMT2EHMT1 | |
| SCHEMBL23260498 | 0.75 | EHMT2 (0.62) | POLBEHMT2EHMT1 | |
| SCHEMBL30526270 | 0.74 | TP53 (0.56) | POLB | |
| SCHEMBL20280946 | 0.74 | TP53 (0.56) | POLB | |
| SCHEMBL10837757 | 0.74 | TP53 (0.56) | POLB | |
| SCHEMBL4356298 | 0.72 | CDK1 (0.54) | PGK1 | |
| SCHEMBL14564131 | 0.70 | KDM1A (0.58) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0225866-B1 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE | Gerot-Pharmazeutika Gesellschaft m.b.H. (AT) | 1991-09-25 | — | — | EP | disclosed |
| US-4795750-A | HYPOTENSIVE AGENTS | GEROT-PHARMAZEUTIKA GESELLSCHAFT (AT) | 1989-01-03 | — | — | US | disclosed |
| EP-0225866-A2 | Quinazoline derivatives, process for their preparation, pharmaceutical compositions containing them and their use | Gerot-Pharmazeutika Gesellschaft m.b.H. (AT) | 1987-06-16 | — | — | EP | disclosed |