Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | CHKA | P35790 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6309417 | 0.84 | ALDH1A1 (0.63) | ALDH1A1MAPK1MCOLN3MEN1KMT2A | |
| SCHEMBL30511075 | 0.82 | ADRB1 (0.63) | ALDH1A1MAPK1MCOLN3MEN1KMT2A | |
| SCHEMBL4328782 | 0.82 | ADRB1 (0.63) | ALDH1A1MAPK1MCOLN3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3649806 | 0.80 | ADRB1 (0.61) | ALDH1A1MAPK1MCOLN3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6965349 | 0.80 | ADRB1 (0.61) | ALDH1A1MAPK1MCOLN3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL29832037 | 0.80 | ADRB1 (0.61) | ALDH1A1MAPK1MCOLN3MEN1KMT2A | |
| SCHEMBL24522235 | 0.79 | ALDH1A1 (0.52) | ALDH1A1MAPK1MCOLN3MEN1KMT2A | |
| SCHEMBL14013835 | 0.79 | ALDH1A1 (0.67) | ALDH1A1MCOLN3MEN1KMT2ANPSR1 | |
| SCHEMBL2941128 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MAPK1MCOLN3MEN1KMT2A | |
| SCHEMBL5106269 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPK1MCOLN3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |