Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | AKT2 | P31751 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | ILK | Q13418 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3637493 | 0.82 | PDE4D (0.49) | KMT2AAKT2ALDH1A1MAPTLMNA | |
| SCHEMBL11307153 | 0.81 | ALDH1A1 (0.45) | KMT2AALDH1A1MAPTLMNACCNA2 | |
| SCHEMBL10488455 | 0.77 | HCAR2 (0.44) | KMT2AAKT2LMNASMN1; SMN2HTT | |
| SCHEMBL1901874 | 0.76 | HTT (0.49) | KMT2AALDH1A1MAPTLMNACCNA2 | |
| SCHEMBL14044117 | 0.71 | HCAR2 (0.61) | KMT2AALDH1A1CCNA2CDK2CCNA1 | |
| SCHEMBL10372596 | 0.70 | MAPT (0.47) | KMT2AALDH1A1MAPTLMNAGRM6 | |
| SCHEMBL8817288 | 0.69 | HTT (0.44) | KMT2AALDH1A1MAPTLMNACCNA2 | |
| Hydrochloric Acid SCHEMBL10372808 | 0.69 | MAPT (0.46) | KMT2AALDH1A1MAPTLMNAGRM6 | |
| SCHEMBL3511548 | 0.69 | JAK2 (0.66) | ALDH1A1SMN1; SMN2GAAJAK2JAK1 | |
| SCHEMBL27527047 | 0.68 | MAPT (0.58) | KMT2AALDH1A1MAPTLMNAGRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129846-B1 | (3-AMINO-1H-PYRAZOL-4-YL)(ARYL)METHANONES | AMERICAN CYANAMID COMPANY (US) | 1991-05-08 | — | — | EP | claimed |
| EP-0129846-A2 | (3-Amino-1H-pyrazol-4-yl)(aryl)methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | claimed |