SCHEMBL9830639

SCHEMBL9830639

Cn1nc(-c2ccc(Cl)cc2F)nc1-c1ccccc1C(F)(F)F

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 19/20 0.67
NR1H2 P55055 1/20 0.41
NR1H3 Q13133 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9829841 0.89 HSD11B1 (0.66) HSD11B1NR1H2NR1H3
SCHEMBL9829439 0.89 HSD11B1 (0.56) HSD11B1NR1H2NR1H3
SCHEMBL9830769 0.88 HSD11B1 (0.53) HSD11B1
SCHEMBL9831595 0.87 HSD11B1 (0.56) HSD11B1NR1H2NR1H3
SCHEMBL9829855 0.86 HSD11B1 (0.53) HSD11B1
SCHEMBL9829408 0.83 HSD11B1 (0.67) HSD11B1
SCHEMBL9830541 0.83 HSD11B1 (0.58) HSD11B1NR1H2NR1H3
SCHEMBL9705543 0.82 HSD11B1 (0.62) HSD11B1
SCHEMBL9832170 0.82 HSD11B1 (0.54) HSD11B1
SCHEMBL9831676 0.82 HSD11B1 (0.53) HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0185256-B1 TRIAZOLE DERIVATES, THEIR PREPARATION AND THEIR USE AS PESTICIDES CIBA-GEIGY AG (CH) 1991-01-30 EP claimed
US-4788210-A PESTICIDES HOFFMANN-LA ROCHE INC. (US) 1988-11-29 US claimed
EP-0185256-A2 Triazole derivates, their preparation and their use as pesticides CIBA-GEIGY AG (CH) 1986-06-25 EP claimed
EP-0185256-B1 TRIAZOLE DERIVATES, THEIR PREPARATION AND THEIR USE AS PESTICIDES CIBA-GEIGY AG (CH) 1991-01-30 EP disclosed
US-4788210-A PESTICIDES HOFFMANN-LA ROCHE INC. (US) 1988-11-29 US disclosed
EP-0185256-A2 Triazole derivates, their preparation and their use as pesticides CIBA-GEIGY AG (CH) 1986-06-25 EP disclosed