Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832038 | 0.92 | SMN1; SMN2 (0.45) | PPARGSMN1; SMN2ALDH1A1LMNANPC1 | |
| SCHEMBL9832874 | 0.83 | CETP (0.47) | PPARGSMN1; SMN2ARALDH1A1LMNA | |
| SCHEMBL9831307 | 0.83 | PPARG (0.43) | PPARGSMN1; SMN2ARALDH1A1LMNA | |
| SCHEMBL9831443 | 0.82 | PPARG (0.50) | PPARGSMN1; SMN2ALDH1A1LMNAUSP2 | |
| SCHEMBL9831449 | 0.81 | SMN1; SMN2 (0.61) | PPARGSMN1; SMN2ALDH1A1CYP4F2CYP4A11 | |
| SCHEMBL9829879 | 0.81 | SMN1; SMN2 (0.43) | PPARGSMN1; SMN2ARCYP4F2CYP4A11 | |
| SCHEMBL9832767 | 0.80 | PPARG (0.62) | PPARGSMN1; SMN2ALDH1A1LMNANPC1 | |
| SCHEMBL20322977 | 0.79 | USP2 (0.41) | PPARGSMN1; SMN2ALDH1A1LMNANPC1 | |
| SCHEMBL9831566 | 0.79 | NLRP3 (0.44) | PPARGSMN1; SMN2ALDH1A1CYP4F2CYP4A11 | |
| SCHEMBL9830030 | 0.78 | SMN1; SMN2 (0.41) | PPARGSMN1; SMN2ARALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |