Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ICAM1 | P05362 | 10/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3489840 | 0.77 | SNCA (1.00) | SNCAGAAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL29636455 | 0.77 | SNCA (1.00) | SNCAGAAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL9831935 | 0.77 | KDM4E (0.61) | GAAMAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL6752502 | 0.77 | MAPT (0.50) | GAAMAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL9831791 | 0.74 | KDM4E (0.47) | GAAMAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL2575044 | 0.73 | MAPT (1.00) | SNCAGAAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL6750365 | 0.72 | ICAM1 (0.55) | GAAMAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL6747412 | 0.71 | GAA (0.47) | GAAMAPTSMN1; SMN2KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL8319061 | 0.71 | KDM4E (0.50) | GAAMAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL8322621 | 0.70 | KDM4E (0.52) | GAAMAPTSMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0140709-B1 | 5-LIPOXYGENASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1991-04-03 | — | — | EP | disclosed |
| US-4634766-A | LIPOXYGENASE INHIBITORS | MERCK FROSST CANADA, INC. (CA) | 1987-01-06 | — | — | US | disclosed |
| EP-0140709-A2 | 5-Lipoxygenase inhibitors | MERCK FROSST CANADA INC. (CA) | 1985-05-08 | — | — | EP | disclosed |