Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CD38 | P28907 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3063558 | 0.86 | NR4A2 (0.71) | NR4A2KDM4ETDP1CRHR1L3MBTL1 | |
| SCHEMBL8966258 | 0.82 | KDM4E (0.69) | NR4A2KDM4ETDP1CRHR1L3MBTL1 | |
| SCHEMBL438980 | 0.81 | NR4A2 (1.00) | NR4A2KDM4ETDP1CRHR1L3MBTL1 | |
| SCHEMBL1026984 | 0.81 | NR4A2 (0.65) | NR4A2KDM4ETDP1CRHR1L3MBTL1 | |
| SCHEMBL1715255 | 0.79 | KDM4E (0.61) | NR4A2KDM4ETDP1CRHR1L3MBTL1 | |
| SCHEMBL24425989 | 0.79 | NR4A2 (0.61) | NR4A2KDM4ETDP1CRHR1L3MBTL1 | |
| SCHEMBL11570729 | 0.79 | NR4A2 (0.61) | NR4A2KDM4ETDP1CRHR1L3MBTL1 | |
| SCHEMBL28046875 | 0.78 | NR4A2 (0.59) | NR4A2KDM4ECRHR1L3MBTL1MAPT | |
| SCHEMBL6726554 | 0.77 | CRHR1 (1.00) | NR4A2KDM4ETDP1CRHR1L3MBTL1 | |
| SCHEMBL11585401 | 0.77 | KDM4E (1.00) | NR4A2KDM4ETDP1CRHR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0096214-B1 | ANTIBACTERIAL PYRIMIDINE COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-02-27 | — | — | EP | disclosed |
| US-4587341-A | BACTERICIDES | BURROUGHS WELLCOME CO. (US) | 1986-05-06 | — | — | US | disclosed |
| EP-0096214-A1 | Antibacterial pyrimidine compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-12-21 | — | — | EP | disclosed |