Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830765 | 0.92 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL9831773 | 0.90 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL9829786 | 0.86 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1ALOX5LTA4HCYP4F2 | |
| SCHEMBL10408046 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1KMT2AMEN1ALOX5 | |
| SCHEMBL9831675 | 0.82 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL10407546 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL9832100 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTKMT2ANPSR1 | |
| SCHEMBL9830014 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL9830529 | 0.80 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1ALOX5LTA4HCYP4F2 | |
| SCHEMBL10408081 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |