Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831191 | 0.92 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2MAPTKMT2AHPGD | |
| SCHEMBL9831675 | 0.90 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2MAPTKMT2AHPGD | |
| SCHEMBL9831773 | 0.82 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2MAPTKMT2AHPGD | |
| SCHEMBL9831307 | 0.80 | PPARG (0.43) | ALDH1A1SMN1; SMN2MAPTKMT2AHPGD | |
| SCHEMBL1025911 | 0.79 | NPSR1 (0.41) | ALDH1A1SMN1; SMN2MAPTKMT2AHPGD | |
| SCHEMBL9831403 | 0.79 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2MAPTLMNAPPARG | |
| SCHEMBL9830030 | 0.78 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2MAPTKMT2AHPGD | |
| SCHEMBL9829786 | 0.77 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2CYP4F2CYP4A11CYP1A2 | |
| SCHEMBL10408046 | 0.76 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2KMT2AMEN1CYP4F2 | |
| SCHEMBL9831566 | 0.76 | NLRP3 (0.44) | ALDH1A1SMN1; SMN2MAPTKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |