Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833391 | 0.95 | MAPT (0.46) | TP53MAPTMEN1POLBKMT2A | |
| SCHEMBL9831879 | 0.93 | MAPT (0.42) | TP53MAPTMEN1POLBKMT2A | |
| SCHEMBL9834152 | 0.92 | MAPT (0.44) | TP53MAPTMEN1POLBKMT2A | |
| SCHEMBL9833365 | 0.91 | TP53 (0.55) | TP53MAPT | |
| SCHEMBL9833948 | 0.89 | ALDH1A1 (0.40) | TP53MAPTMEN1POLBKMT2A | |
| SCHEMBL9834840 | 0.89 | MAPT (0.44) | TP53MAPTMEN1POLBKMT2A | |
| SCHEMBL9832532 | 0.88 | ALDH1A1 (0.42) | TP53MAPTMEN1POLBKMT2A | |
| SCHEMBL9831845 | 0.87 | TP53 (0.57) | TP53MAPTCNR1 | |
| SCHEMBL9834096 | 0.87 | MAPT (0.49) | TP53MAPTLMNACNR1 | |
| SCHEMBL9834242 | 0.87 | MAPT (0.50) | TP53MAPTDHODHLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274443-A1 | Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-13 | — | — | EP | claimed |
| EP-0274443-B1 | HETEROARYL 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-05-29 | — | — | EP | disclosed |
| US-4816467-A | BACTERICIDES, VIRICIDES | FARMITALIA CARLO ERBA S.R.L (IT) | 1989-03-28 | — | — | US | disclosed |
| EP-0274443-A1 | Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-13 | — | — | EP | disclosed |