Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22909290 | 0.98 | MAPK1 (0.50) | ALDH1A1SMN1; SMN2TSHRMAPTPKM | |
| SCHEMBL19998621 | 0.82 | TSHR (0.57) | ALDH1A1SMN1; SMN2TSHRMAPTPKM | |
| SCHEMBL25539403 | 0.81 | TSHR (0.47) | ALDH1A1SMN1; SMN2TSHRMAPTPKM | |
| SCHEMBL29728648 | 0.81 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2TSHRMAPTPKM | |
| SCHEMBL238269 | 0.81 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2TSHRMAPTPKM | |
| SCHEMBL6582872 | 0.79 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2MAPTLMNAGAA | |
| SCHEMBL14922280 | 0.79 | MAPT (0.53) | ALDH1A1SMN1; SMN2MAPTMAPK1CYP1A2 | |
| SCHEMBL8059865 | 0.79 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2TSHRMAPTPKM | |
| SCHEMBL13713592 | 0.79 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2TSHRMAPTPKM | |
| SCHEMBL28172136 | 0.79 | TSHR (0.42) | ALDH1A1SMN1; SMN2TSHRMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |