Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829162 | 0.82 | TOP2A (0.51) | POLBNLRP3LMNATOP2ACYP1A2 | |
| SCHEMBL9832748 | 0.81 | POLB (0.46) | POLBL3MBTL1NLRP3SYKLMNA | |
| SCHEMBL9831819 | 0.81 | LMNA (0.41) | POLBL3MBTL1NLRP3SYKLMNA | |
| SCHEMBL18451634 | 0.78 | GAA (0.39) | NLRP3LMNASMN1; SMN2GAAMEN1 | |
| SCHEMBL9832125 | 0.78 | ABCB1 (0.47) | POLBL3MBTL1NLRP3SMN1; SMN2TOP2A | |
| SCHEMBL9832469 | 0.78 | MAPT (0.42) | POLBL3MBTL1LMNASMN1; SMN2TOP2A | |
| SCHEMBL9831031 | 0.72 | POLB (0.43) | POLBL3MBTL1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL9830011 | 0.72 | L3MBTL1 (0.43) | POLBL3MBTL1NLRP3LMNASMN1; SMN2 | |
| SCHEMBL9829371 | 0.72 | L3MBTL1 (0.43) | POLBL3MBTL1NLRP3LMNASMN1; SMN2 | |
| SCHEMBL9829791 | 0.72 | LMNA (0.41) | POLBL3MBTL1NLRP3LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |