Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 15/20 | 0.77 |
| ▸ | CHEK1 | O14757 | 14/20 | 0.77 |
| ▸ | PARP1 | P09874 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | CCND1 | P24385 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.53 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.53 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829286 | 0.87 | WEE1 (1.00) | WEE1CHEK1KDRCDK4CDK2 | |
| SCHEMBL9832776 | 0.82 | WEE1 (0.75) | WEE1CHEK1PARP1KDRCCNE2 | |
| SCHEMBL9834200 | 0.81 | MAP3K9 (0.58) | WEE1CHEK1PARP1KDRROCK2 | |
| SCHEMBL10405623 | 0.81 | WEE1 (0.76) | WEE1CHEK1PARP1KDRCDK2 | |
| SCHEMBL5828676 | 0.79 | WEE1 (0.84) | WEE1CHEK1KDRCDK2CAMK2D | |
| SCHEMBL9832547 | 0.79 | WEE1 (0.74) | WEE1CHEK1PARP1CCNE2CDK4 | |
| SCHEMBL9832534 | 0.77 | WEE1 (0.78) | WEE1CHEK1PARP1KDRCCNE2 | |
| SCHEMBL5828702 | 0.76 | WEE1 (1.00) | WEE1CHEK1CDK4 | |
| SCHEMBL5829093 | 0.76 | WEE1 (0.78) | WEE1CHEK1KDRROCK2CDK2 | |
| SCHEMBL5828673 | 0.76 | PARP1 (1.00) | WEE1CHEK1PARP1ROCK2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0362695-B1 | PYRROLOCARBAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1991-04-03 | — | — | EP | disclosed |
| US-4912107-A | Pyrrolocarbazole derivatives, compositions containing them, and methods for using them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1990-03-27 | — | — | US | disclosed |