Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 1.00 |
| ▸ | CDK4 | P11802 | 8/20 | 0.61 |
| ▸ | CCND1 | P24385 | 8/20 | 0.61 |
| ▸ | CAMK2B | Q13554 | 6/20 | 0.61 |
| ▸ | CAMK2G | Q13555 | 6/20 | 0.61 |
| ▸ | CAMK2D | Q13557 | 6/20 | 0.61 |
| ▸ | CAMK2A | Q9UQM7 | 6/20 | 0.61 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.61 |
| ▸ | CDK2 | P24941 | 6/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.61 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.61 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.61 |
| ▸ | CDK1 | P06493 | 3/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.61 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | PRKCG | P05129 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832547 | 0.79 | WEE1 (0.74) | PARP1CDK4CCND1CAMK2BCAMK2G | |
| SCHEMBL9832776 | 0.77 | WEE1 (0.75) | PARP1CDK4CCND1CAMK2BCAMK2G | |
| Staurosporine Aglycon SCHEMBL29406635 | 0.76 | CDK4 (1.00) | PARP1CDK4CCND1CAMK2BCAMK2G | |
| Staurosporine Aglycon SCHEMBL30530825 | 0.76 | CDK4 (1.00) | PARP1CDK4CCND1CAMK2BCAMK2G | |
| Staurosporine Aglycon SCHEMBL8124103 | 0.76 | CDK4 (1.00) | PARP1CDK4CCND1CAMK2BCAMK2G | |
| SCHEMBL10405623 | 0.76 | WEE1 (0.76) | PARP1CAMK2DCDK2CDK5CDK1 | |
| SCHEMBL9832075 | 0.76 | WEE1 (0.77) | PARP1CDK4CCND1CAMK2BCAMK2G | |
| SCHEMBL22566985 | 0.75 | CDK4 (0.74) | PARP1CDK4CCND1CAMK2BCAMK2G | |
| SCHEMBL29516962 | 0.74 | PARP1 (1.00) | PARP1CDK4CCND1CAMK2BCAMK2G | |
| SCHEMBL5381581 | 0.74 | PARP1 (1.00) | PARP1CDK4CCND1CAMK2BCAMK2G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |