Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 17/20 | 0.75 |
| ▸ | CHEK1 | O14757 | 16/20 | 0.75 |
| ▸ | PARP1 | P09874 | 2/20 | 0.62 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.56 |
| ▸ | PRKACA | P17612 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.56 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | LTK | P29376 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828819 | 0.86 | WEE1 (1.00) | WEE1CHEK1PRKCQPRKACACDK2 | |
| SCHEMBL10405623 | 0.85 | WEE1 (0.76) | WEE1CHEK1PARP1PRKCQPRKACA | |
| SCHEMBL5829093 | 0.83 | WEE1 (0.78) | WEE1CHEK1PRKCQPRKACACDK2 | |
| SCHEMBL9832547 | 0.83 | WEE1 (0.74) | WEE1CHEK1PARP1PRKCQPRKACA | |
| SCHEMBL9832075 | 0.82 | WEE1 (0.77) | WEE1CHEK1PARP1CDK2CAMK2D | |
| SCHEMBL9832534 | 0.81 | WEE1 (0.78) | WEE1CHEK1PARP1PRKCQPRKACA | |
| SCHEMBL5828688 | 0.77 | WEE1 (0.75) | WEE1CHEK1PRKCQPRKACACDK2 | |
| SCHEMBL5828673 | 0.77 | PARP1 (1.00) | WEE1CHEK1PARP1PRKCQPRKACA | |
| SCHEMBL30462649 | 0.75 | KDM4E (0.48) | WEE1CHEK1PARP1MEN1KMT2A | |
| SCHEMBL29038330 | 0.75 | KDM4E (0.48) | WEE1CHEK1PARP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0362695-B1 | PYRROLOCARBAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1991-04-03 | — | — | EP | disclosed |
| US-4912107-A | Pyrrolocarbazole derivatives, compositions containing them, and methods for using them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1990-03-27 | — | — | US | disclosed |