Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 15/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832954 | 0.85 | BCHE (0.64) | NOX1HDAC6BCHEPOLBACHE | |
| SCHEMBL18612766 | 0.84 | NOX1 (0.68) | NOX1BCHEPOLBATMACHE | |
| SCHEMBL25388003 | 0.84 | NOX1 (0.68) | NOX1HDAC6BCHEPOLBATM | |
| SCHEMBL6747160 | 0.80 | NOX1 (0.37) | NOX1HDAC6SNCA | |
| SCHEMBL9830999 | 0.79 | SNCA (0.54) | NOX1BCHEACHESNCAALOX15 | |
| SCHEMBL30198410 | 0.77 | NOX1 (1.00) | NOX1BCHEPOLBATMACHE | |
| SCHEMBL341905 | 0.77 | NOX1 (1.00) | NOX1BCHEPOLBATMACHE | |
| SCHEMBL9832554 | 0.76 | MAOA (0.55) | NOX1HDAC6POLBSMN1; SMN2GAA | |
| SCHEMBL9832223 | 0.74 | HDAC6 (0.59) | HDAC6MAPT | |
| SCHEMBL12165688 | 0.73 | HDAC6 (0.43) | NOX1HDAC6BCHESMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0140709-B1 | 5-LIPOXYGENASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1991-04-03 | — | — | EP | disclosed |
| US-4634766-A | LIPOXYGENASE INHIBITORS | MERCK FROSST CANADA, INC. (CA) | 1987-01-06 | — | — | US | disclosed |
| EP-0140709-A2 | 5-Lipoxygenase inhibitors | MERCK FROSST CANADA INC. (CA) | 1985-05-08 | — | — | EP | disclosed |