Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831622 | 0.82 | NPSR1 (0.54) | HDAC6KMT2ALMNAMEN1THRB | |
| SCHEMBL12311066 | 0.78 | MEN1 (0.69) | KMT2ALMNAMEN1MAPTALDH1A1 | |
| SCHEMBL9832621 | 0.74 | NOX1 (0.61) | HDAC6MAPT | |
| SCHEMBL9833656 | 0.72 | CYP2D6 (0.66) | HDAC6KMT2ALMNAMEN1MAPT | |
| SCHEMBL9832954 | 0.71 | BCHE (0.64) | HDAC6LMNAMAPTTP53 | |
| SCHEMBL9832554 | 0.71 | MAOA (0.55) | HDAC6KMT2ALMNAMEN1MAPT | |
| SCHEMBL6749056 | 0.70 | CA12 (0.38) | KMT2ALMNAMEN1TP53ALDH1A1 | |
| SCHEMBL11883702 | 0.70 | MEN1 (0.53) | KMT2ALMNAMEN1MAPTALDH1A1 | |
| SCHEMBL6747868 | 0.69 | ALDH1A1 (0.43) | LMNATP53ALDH1A1 | |
| SCHEMBL15775866 | 0.69 | MEN1 (0.55) | HDAC6KMT2ALMNAMEN1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0140709-B1 | 5-LIPOXYGENASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1991-04-03 | — | — | EP | disclosed |
| US-4634766-A | LIPOXYGENASE INHIBITORS | MERCK FROSST CANADA, INC. (CA) | 1987-01-06 | — | — | US | disclosed |
| EP-0140709-A2 | 5-Lipoxygenase inhibitors | MERCK FROSST CANADA INC. (CA) | 1985-05-08 | — | — | EP | disclosed |