Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | UTRN | P46939 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831245 | 0.83 | KDM4E (0.52) | NOTUMALOX15ALDH1A1RAB9AKDM4E | |
| SCHEMBL9833185 | 0.81 | IKBKB (0.50) | NOTUMALOX15MAPTRAB9ANPC1 | |
| SCHEMBL8989246 | 0.79 | IKBKB (0.49) | NOTUMMAPTALDH1A1RAB9AKDM4E | |
| SCHEMBL18003372 | 0.77 | NOTUM (0.44) | NOTUMALOX15UTRNMAPTALDH1A1 | |
| SCHEMBL1553828 | 0.77 | NPC1 (0.49) | NOTUMMAPTALDH1A1RAB9AKDM4E | |
| SCHEMBL9831294 | 0.76 | NPC1 (0.44) | ALOX15ALDH1A1RAB9AKDM4EHSD17B10 | |
| SCHEMBL9831905 | 0.76 | NOTUM (0.44) | NOTUMESR1ESR2 | |
| SCHEMBL6377222 | 0.76 | KDM4E (0.51) | NOTUMRAB9AKDM4ENPC1IKBKB | |
| SCHEMBL9830290 | 0.74 | KDM4E (0.41) | MAPTALDH1A1RAB9AKDM4EHSD17B10 | |
| SCHEMBL5639362 | 0.74 | TARBP2 (0.54) | MAPTALDH1A1RAB9AKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220573-B1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4774253-A | ETHER,-ACIDS, ESTERS OR AMIDES | HOFFMANN-LA ROCHE INC. (US) | 1988-09-27 | — | — | US | disclosed |
| EP-0220573-A1 | Heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1987-05-06 | — | — | EP | disclosed |