Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829464 | 0.88 | SLC16A3 (0.39) | TYRF10NPSR1 | |
| SCHEMBL9832622 | 0.81 | POLB (0.56) | POLBL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9830325 | 0.80 | POLB (0.45) | POLBMRGPRX4L3MBTL1MAPTALDH1A1 | |
| SCHEMBL4068333 | 0.72 | NOTUM (0.57) | F10NPSR1POLBKDM4EL3MBTL1 | |
| SCHEMBL17232511 | 0.72 | NOTUM (0.38) | TYRF10NPSR1POLBKDM4E | |
| SCHEMBL9831414 | 0.69 | SMN1; SMN2 (0.56) | POLBL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9830377 | 0.69 | POLB (0.55) | POLBL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3369897 | 0.69 | NOTUM (0.38) | TYRF10NPSR1POLBKDM4E | |
| SCHEMBL9830636 | 0.68 | POLB (0.54) | POLBL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL17229342 | 0.68 | SMN1; SMN2 (0.40) | F10KDM4EMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220573-B1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4774253-A | ETHER,-ACIDS, ESTERS OR AMIDES | HOFFMANN-LA ROCHE INC. (US) | 1988-09-27 | — | — | US | disclosed |
| EP-0220573-A1 | Heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1987-05-06 | — | — | EP | disclosed |