Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GALR2 | O43603 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488888 | 0.84 | NPSR1 (0.45) | KMT2ANPSR1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9831423 | 0.82 | MAPT (0.40) | KMT2ANPSR1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL10566019 | 0.81 | SMN1; SMN2 (0.55) | KMT2APOLBSMN1; SMN2ALDH1A1MITF | |
| SCHEMBL2510167 | 0.80 | ALDH3A1 (0.42) | KMT2ANPSR1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9833125 | 0.79 | MAPT (0.54) | KMT2ANPSR1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9833300 | 0.79 | NPSR1 (0.45) | KMT2ANPSR1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9829837 | 0.77 | TDP1 (0.40) | KMT2ANPSR1POLBALDH1A1LMNA | |
| SCHEMBL2490045 | 0.76 | KMT2A (0.42) | KMT2ANPSR1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL10534374 | 0.76 | PGR (0.44) | KMT2ANPSR1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9383682 | 0.76 | NPSR1 (0.42) | KMT2ANPSR1POLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |
| EP-0161632-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |