Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 9/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.41 |
| ▸ | PDE4A | P27815 | 7/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835229 | 0.78 | PGR (0.31) | PGR | |
| SCHEMBL9834972 | 0.76 | ATAD2 (0.50) | ATAD2PDK2PDK4PGRPDE3B | |
| SCHEMBL9836092 | 0.74 | ATAD2 (0.49) | ATAD2PDK2PDK4PGRPDE3B | |
| SCHEMBL9835182 | 0.74 | ATAD2 (0.49) | ATAD2PDK2PDK4PGRPDE3B | |
| SCHEMBL10667579 | 0.74 | ATAD2 (0.49) | ATAD2PDK2PDK4PGRPDE3B | |
| SCHEMBL10669580 | 0.74 | ATAD2 (0.45) | ATAD2PDK2PDK4PGRPDE3B | |
| SCHEMBL10505209 | 0.73 | AHR (0.46) | ATAD2PDK2PDK4PGRPDE3B | |
| Bromide SCHEMBL10555130 | 0.73 | ATAD2 (0.47) | ATAD2PDK2PDK4PGRPDE3B | |
| SCHEMBL24690661 | 0.72 | PGR (0.53) | ATAD2PDK2PDK4PGRPDE3B | |
| SCHEMBL4138321 | 0.72 | ATAD2 (0.50) | ATAD2PDK2PDK4PGRPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | claimed |
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |