Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | MAX | P61244 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832248 | 0.96 | MAPT (0.40) | MAPTGAAALDH1A1TDP1NPC1 | |
| SCHEMBL11024217 | 0.90 | MAPT (0.48) | MAPTGAAALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL9832605 | 0.89 | MAPT (0.42) | MAPTGAAALDH1A1TDP1HCAR3 | |
| SCHEMBL9832415 | 0.89 | MAPT (0.51) | MAPTGAAALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL9833084 | 0.85 | MAPT (0.51) | MAPTGAAALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL9833059 | 0.85 | HCAR3 (0.40) | MAPTGAAALDH1A1TDP1HCAR3 | |
| SCHEMBL9832176 | 0.85 | MAPT (0.38) | MAPTGAAALDH1A1TDP1HCAR3 | |
| SCHEMBL9831073 | 0.84 | HCAR3 (0.42) | MAPTGAAALDH1A1TDP1HCAR3 | |
| SCHEMBL9833347 | 0.84 | MAPT (0.39) | MAPTGAAALDH1A1TDP1HCAR3 | |
| SCHEMBL11025524 | 0.83 | MAPT (0.52) | MAPTGAAALDH1A1HCAR3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |