Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.40 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.40 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.40 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.40 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.40 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.40 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.40 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.40 |
| ▸ | PSMA6 | P60900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832248 | 0.84 | MAPT (0.40) | MAPTALDH1A1GAAPSMB11PSMA7 | |
| SCHEMBL9833084 | 0.81 | MAPT (0.51) | MAPTALDH1A1GAAKMT2APOLB | |
| SCHEMBL9833672 | 0.80 | MAPT (0.38) | MAPTALDH1A1GAAPSMB11PSMA7 | |
| SCHEMBL9832943 | 0.79 | MAPT (0.39) | MAPTALDH1A1PSMB11PSMA7PSMB1 | |
| SCHEMBL11024217 | 0.78 | MAPT (0.48) | MAPTALDH1A1GAAKMT2APOLB | |
| SCHEMBL9832415 | 0.77 | MAPT (0.51) | MAPTALDH1A1GAAKMT2APOLB | |
| SCHEMBL9832325 | 0.76 | MAPT (0.39) | MAPTALDH1A1PSMB11PSMA7PSMB1 | |
| SCHEMBL9833238 | 0.74 | NQO2 (0.55) | MAPTALDH1A1GAANQO2KMT2A | |
| SCHEMBL9833300 | 0.68 | NPSR1 (0.45) | MAPTALDH1A1GAANPSR1KMT2A | |
| SCHEMBL9833492 | 0.68 | MAPT (0.40) | MAPTALDH1A1GAAKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |
| EP-0161632-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |