Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 6/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462300 | 0.80 | HDAC8 (0.81) | HDAC8HDAC6TBXAS1TBXA2R | |
| SCHEMBL441790 | 0.79 | HDAC8 (1.00) | HDAC8HDAC6 | |
| SCHEMBL9452869 | 0.78 | HDAC8 (0.68) | HDAC8HDAC6TBXAS1TBXA2R | |
| SCHEMBL9452893 | 0.77 | HDAC8 (0.64) | HDAC8HDAC6TBXAS1TBXA2R | |
| SCHEMBL1282031 | 0.71 | HDAC8 (0.56) | HDAC8RORC | |
| SCHEMBL2221395 | 0.70 | HDAC8 (0.50) | HDAC8HSD11B1 | |
| SCHEMBL2221393 | 0.70 | HDAC8 (0.50) | HDAC8HSD11B1 | |
| SCHEMBL783637 | 0.69 | SMN1; SMN2 (0.56) | HDAC8RORC | |
| Bicarbonate SCHEMBL15226047 | 0.69 | NAMPT (0.57) | HDAC8 | |
| SCHEMBL15225912 | 0.68 | SMN1; SMN2 (0.59) | HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430459-A1 | Tetrahydronaphthalene derivatives and preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1991-06-05 | — | — | EP | disclosed |