SCHEMBL462300

SCHEMBL462300

O=C(O)c1ccc2c(c1)CC(NS(=O)(=O)c1cccnc1)CC2

nearest known ligand 0.81

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 14/20 0.81
HDAC6 Q9UBN7 5/20 0.56
TBXAS1 P24557 3/20 0.53
TBXA2R P21731 2/20 0.53
ADRB3 P13945 2/20 0.51
HDAC1 Q13547 2/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC9 Q9UKV0 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL441790 0.90 HDAC8 (1.00) HDAC8HDAC6HDAC1HDAC7HDAC9
SCHEMBL9452869 0.85 HDAC8 (0.68) HDAC8HDAC6TBXAS1TBXA2R
SCHEMBL9833792 0.80 HDAC8 (0.65) HDAC8HDAC6TBXAS1TBXA2R
SCHEMBL9452893 0.79 HDAC8 (0.64) HDAC8HDAC6TBXAS1TBXA2R
SCHEMBL354885 0.78 HDAC8 (0.80) HDAC8HDAC6
SCHEMBL10405754 0.78 APOB (0.57) HDAC8HDAC6TBXA2R
SCHEMBL355191 0.77 HDAC8 (0.59) HDAC8HDAC6
SCHEMBL9203595 0.76 TBXAS1 (0.70) HDAC8HDAC6TBXAS1TBXA2R
SCHEMBL1282031 0.76 HDAC8 (0.56) HDAC8
Bicarbonate SCHEMBL15226047 0.75 NAMPT (0.57) HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2613775-A1 NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER F.HOFFMANN-LA ROCHE AG (CH) 2013-07-17 EP claimed
WO-2012031993-A1 NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER F. HOFFMANN-LA ROCHE AG (CH) 2012-03-15 WO claimed